reference strain c albicans atcc 10231 Search Results


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ATCC 128 candida albicans atcc 10231 type strain 128 candida auris cau 1 clinical
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ATCC t5 caption a7 yeast strains kanb 3a 3b 3c 3d 3e 4c 4d pos itc flc c albicans atcc 10231
MIC Values ( μ g/mL) a of KANA, <t> KANB, </t> 3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains
T5 Caption A7 Yeast Strains Kanb 3a 3b 3c 3d 3e 4c 4d Pos Itc Flc C Albicans Atcc 10231, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ATCC bacterial strains
MIC Values ( μ g/mL) a of KANA, <t> KANB, </t> 3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains
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ATCC candida tropicalis
MIC Values ( μ g/mL) a of KANA, <t> KANB, </t> 3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains
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Image Search Results


MIC Values ( μ g/mL) a of KANA,  KANB,  3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: MIC Values ( μ g/mL) a of KANA, KANB, 3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques:

Bar graph displaying the relative initial rates of reactions of the various AMEs with KANB and its derivatives 3a–e and 4c, d. Rates are normalized to KANB.

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: Bar graph displaying the relative initial rates of reactions of the various AMEs with KANB and its derivatives 3a–e and 4c, d. Rates are normalized to KANB.

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques:

MIC Values ( μ g/mL) Determined for  KANB,  Its Derivatives 3a–e and 4c, d, and Three Control Antifungal Agents (POS, ITC, and FLC) against Various Yeast Strains and Filamentous Fungi a

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: MIC Values ( μ g/mL) Determined for KANB, Its Derivatives 3a–e and 4c, d, and Three Control Antifungal Agents (POS, ITC, and FLC) against Various Yeast Strains and Filamentous Fungi a

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques: Control

Representative time-kill studies of KANB derivatives 3c and 3d against azole-resistant C. albicans ATCC 64124 (strain B). (A) Cultures were exposed to 3c at 8 μg/mL (○), 16 μg/mL (▼), and 32 μg/mL (△). (B) Cultures were exposed to 3d at 2 μg/mL (○), 4 μg/mL (▼), and 8 μg/mL (△). In both panels, cultures were exposed to AmB at 1 μg/mL (■) or to a no drug control (●).

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: Representative time-kill studies of KANB derivatives 3c and 3d against azole-resistant C. albicans ATCC 64124 (strain B). (A) Cultures were exposed to 3c at 8 μg/mL (○), 16 μg/mL (▼), and 32 μg/mL (△). (B) Cultures were exposed to 3d at 2 μg/mL (○), 4 μg/mL (▼), and 8 μg/mL (△). In both panels, cultures were exposed to AmB at 1 μg/mL (■) or to a no drug control (●).

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques: Control

(A) Representative dose-dependent membrane permeabilization effects of KANB and its derivatives 3c and 3d on azole-resistant C. albicans ATCC 64124 (B). From top to bottom: Propidium iodine (PI) dye uptake by yeast cells without drug, with KANB (62.5 μg/mL), with 3c (1× and 2× MIC), and with 3d (1× and 2× MIC). (B) Quantitative representation of the images shown in panel A.

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: (A) Representative dose-dependent membrane permeabilization effects of KANB and its derivatives 3c and 3d on azole-resistant C. albicans ATCC 64124 (B). From top to bottom: Propidium iodine (PI) dye uptake by yeast cells without drug, with KANB (62.5 μg/mL), with 3c (1× and 2× MIC), and with 3d (1× and 2× MIC). (B) Quantitative representation of the images shown in panel A.

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques: Membrane

Hemolytic activity of KANB, gramicidin, amphotericin B (AmB), and 3a–e on mouse red blood cells.

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: Hemolytic activity of KANB, gramicidin, amphotericin B (AmB), and 3a–e on mouse red blood cells.

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques: Activity Assay

Mammalian cell cytotoxicity of KANB and its derivatives 3a–d against (A) A549 cell line and (B) BEAS-2B cell line.

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles

doi: 10.1021/acs.jmedchem.5b01375

Figure Lengend Snippet: Mammalian cell cytotoxicity of KANB and its derivatives 3a–d against (A) A549 cell line and (B) BEAS-2B cell line.

Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored" t5 caption a7 yeast strains KANB 3a 3b 3c 3d 3e 4c 4d POS ITC FLC C. albicans ATCC 10231 ( A ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 0.5 0.5 62.5 C. albicans ATCC 64124 ( B ) b >125 >125 125 31.2 7.8 3.9 31.2 3.9 >62.5 >62.5 >125 C. albicans ATCC MYA-2876 ( C ) c >125 >125 125 31.2 7.8 3.9 31.2 3.9 7.8 7.8 15.6 C. albicans ATCC 90819 ( D ) b >125 >125 125 31.2 15.6 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-2310 ( E ) c >125 >125 62.5 7.8 7.8 3.9 62.5 7.8 31.2 31.2 >125 C. albicans ATCC MYA-1237 ( F ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 C. albicans ATCC MYA-1003 ( G ) b >125 >125 125 31.2 7.8 3.9 62.5 7.8 15.6 31.2 62.5 Filamentous Fungi Aspergillus nidulans ATCC 38163 ( H ) >125 15.6 ≤1.95 ≤1.95 ≤1.95 1.95 3.9 1.95 ≤1.95 ≤1.95 >62.5 Open in a separate window a All experiments were performed in duplicate.

Techniques: