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Image Search Results
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: MIC Values ( μ g/mL) a of KANA, KANB, 3a–e, and 4c, d against Various Gram-Positive and Gram-Negative Bacterial Strains
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques:
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: Bar graph displaying the relative initial rates of reactions of the various AMEs with KANB and its derivatives 3a–e and 4c, d. Rates are normalized to KANB.
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques:
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: MIC Values ( μ g/mL) Determined for KANB, Its Derivatives 3a–e and 4c, d, and Three Control Antifungal Agents (POS, ITC, and FLC) against Various Yeast Strains and Filamentous Fungi a
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques: Control
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: Representative time-kill studies of KANB derivatives 3c and 3d against azole-resistant C. albicans ATCC 64124 (strain B). (A) Cultures were exposed to 3c at 8 μg/mL (○), 16 μg/mL (▼), and 32 μg/mL (△). (B) Cultures were exposed to 3d at 2 μg/mL (○), 4 μg/mL (▼), and 8 μg/mL (△). In both panels, cultures were exposed to AmB at 1 μg/mL (■) or to a no drug control (●).
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques: Control
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: (A) Representative dose-dependent membrane permeabilization effects of KANB and its derivatives 3c and 3d on azole-resistant C. albicans ATCC 64124 (B). From top to bottom: Propidium iodine (PI) dye uptake by yeast cells without drug, with KANB (62.5 μg/mL), with 3c (1× and 2× MIC), and with 3d (1× and 2× MIC). (B) Quantitative representation of the images shown in panel A.
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques: Membrane
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: Hemolytic activity of KANB, gramicidin, amphotericin B (AmB), and 3a–e on mouse red blood cells.
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques: Activity Assay
Journal: Journal of medicinal chemistry
Article Title: Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles
doi: 10.1021/acs.jmedchem.5b01375
Figure Lengend Snippet: Mammalian cell cytotoxicity of KANB and its derivatives 3a–d against (A) A549 cell line and (B) BEAS-2B cell line.
Article Snippet: This is in agreement with our results showing that, as with bacteria, 3d may also be able to delay the development of resistance by fungi ( Figure S27 ). table ft1 table-wrap mode="anchored"
Techniques: